Investigation of morphometric variability of subthalamic nucleus, red nucleus, and substantia nigra in advanced Parkinson's disease patients using automatic segmentation and PCA-based analysis.
Identifieur interne : 000A24 ( Main/Exploration ); précédent : 000A23; suivant : 000A25Investigation of morphometric variability of subthalamic nucleus, red nucleus, and substantia nigra in advanced Parkinson's disease patients using automatic segmentation and PCA-based analysis.
Auteurs : Yiming Xiao [Canada] ; Pierre Jannin ; Tiziano D'Albis ; Nicolas Guizard ; Claire Haegelen ; Florent Lalys ; Marc Vérin ; D Louis CollinsSource :
- Human brain mapping [ 1097-0193 ] ; 2014.
English descriptors
- KwdEn :
- Atlases as Topic, Cohort Studies, Female, Humans, Image Processing, Computer-Assisted (methods), Magnetic Resonance Imaging (methods), Male, Middle Aged, Parkinson Disease (pathology), Pattern Recognition, Automated (methods), Principal Component Analysis, Red Nucleus (pathology), Substantia Nigra (pathology), Subthalamic Nucleus (pathology).
- MESH :
Abstract
Subthalamic nucleus (STN) deep brain stimulation (DBS) is an effective surgical therapy to treat Parkinson's disease (PD). Conventional methods employ standard atlas coordinates to target the STN, which, along with the adjacent red nucleus (RN) and substantia nigra (SN), are not well visualized on conventional T1w MRIs. However, the positions and sizes of the nuclei may be more variable than the standard atlas, thus making the pre-surgical plans inaccurate. We investigated the morphometric variability of the STN, RN and SN by using label-fusion segmentation results from 3T high resolution T2w MRIs of 33 advanced PD patients. In addition to comparing the size and position measurements of the cohort to the Talairach atlas, principal component analysis (PCA) was performed to acquire more intuitive and detailed perspectives of the measured variability. Lastly, the potential correlation between the variability shown by PCA results and the clinical scores was explored.
DOI: 10.1002/hbm.22478
PubMed: 24652699
Affiliations:
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Disease</term><term>Red Nucleus</term><term>Substantia Nigra</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Atlases as Topic</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Principal Component Analysis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Subthalamic nucleus (STN) deep brain stimulation (DBS) is an effective surgical therapy to treat Parkinson's disease (PD). Conventional methods employ standard atlas coordinates to target the STN, which, along with the adjacent red nucleus (RN) and substantia nigra (SN), are not well visualized on conventional T1w MRIs. However, the positions and sizes of the nuclei may be more variable than the standard atlas, thus making the pre-surgical plans inaccurate. We investigated the morphometric variability of the STN, RN and SN by using label-fusion segmentation results from 3T high resolution T2w MRIs of 33 advanced PD patients. In addition to comparing the size and position measurements of the cohort to the Talairach atlas, principal component analysis (PCA) was performed to acquire more intuitive and detailed perspectives of the measured variability. Lastly, the potential correlation between the variability shown by PCA results and the clinical scores was explored.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><noCountry><name sortKey="Collins, D Louis" sort="Collins, D Louis" uniqKey="Collins D" first="D Louis" last="Collins">D Louis Collins</name><name sortKey="D Albis, Tiziano" sort="D Albis, Tiziano" uniqKey="D Albis T" first="Tiziano" last="D'Albis">Tiziano D'Albis</name><name sortKey="Guizard, Nicolas" sort="Guizard, Nicolas" uniqKey="Guizard N" first="Nicolas" last="Guizard">Nicolas Guizard</name><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name><name sortKey="Jannin, Pierre" sort="Jannin, Pierre" uniqKey="Jannin P" first="Pierre" last="Jannin">Pierre Jannin</name><name sortKey="Lalys, Florent" sort="Lalys, Florent" uniqKey="Lalys F" first="Florent" last="Lalys">Florent Lalys</name><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name></noCountry><country name="Canada"><region name="Québec"><name sortKey="Xiao, Yiming" sort="Xiao, Yiming" uniqKey="Xiao Y" first="Yiming" last="Xiao">Yiming Xiao</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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